Testing of chloroquine and quinacrine for mutagenicity in Drosophila melanogaster

N. Xamena, A. Creus, A. Velázquez, R. Marcos

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)


To extend the data on the mutagenic effects of intercalating agents in Drosophila melanogaster, chloroquine and quinacrine were tested for the induction of genetic damage in D. melanogaster males. Sex-linked recessive lethals and sex-chromosome loss induction were studied following treatment of adult males using a feeding technique. Our results show that both intercalating compounds increase significantly the frequency of sex-linked recessive lethals, but are unable to induce sex-chromosome loss in male germ cells under the conditions of testing. © 1985.
Original languageEnglish
Pages (from-to)177-180
JournalMutation Research/Genetic Toxicology
Publication statusPublished - 1 Jan 1985


Dive into the research topics of 'Testing of chloroquine and quinacrine for mutagenicity in Drosophila melanogaster'. Together they form a unique fingerprint.

Cite this