Testing of chloroquine and quinacrine for mutagenicity in Drosophila melanogaster

N. Xamena; A. Creus; A. Velázquez; R. Marcos

doi:https://doi.org/10.1016/0165-1218(85)90081-3

Testing of chloroquine and quinacrine for mutagenicity in Drosophila melanogaster

N. Xamena, A. Creus, A. Velázquez, R. Marcos

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Abstract

To extend the data on the mutagenic effects of intercalating agents in Drosophila melanogaster, chloroquine and quinacrine were tested for the induction of genetic damage in D. melanogaster males. Sex-linked recessive lethals and sex-chromosome loss induction were studied following treatment of adult males using a feeding technique. Our results show that both intercalating compounds increase significantly the frequency of sex-linked recessive lethals, but are unable to induce sex-chromosome loss in male germ cells under the conditions of testing. © 1985.

Original language	English
Pages (from-to)	177-180
Journal	Mutation Research/Genetic Toxicology
Volume	158
DOIs	https://doi.org/10.1016/0165-1218(85)90081-3
Publication status	Published - 1 Jan 1985

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title = "Testing of chloroquine and quinacrine for mutagenicity in Drosophila melanogaster",

abstract = "To extend the data on the mutagenic effects of intercalating agents in Drosophila melanogaster, chloroquine and quinacrine were tested for the induction of genetic damage in D. melanogaster males. Sex-linked recessive lethals and sex-chromosome loss induction were studied following treatment of adult males using a feeding technique. Our results show that both intercalating compounds increase significantly the frequency of sex-linked recessive lethals, but are unable to induce sex-chromosome loss in male germ cells under the conditions of testing. {\textcopyright} 1985.",

author = "N. Xamena and A. Creus and A. Vel{\'a}zquez and R. Marcos",

year = "1985",

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AU - Xamena, N.

AU - Creus, A.

AU - Velázquez, A.

AU - Marcos, R.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - To extend the data on the mutagenic effects of intercalating agents in Drosophila melanogaster, chloroquine and quinacrine were tested for the induction of genetic damage in D. melanogaster males. Sex-linked recessive lethals and sex-chromosome loss induction were studied following treatment of adult males using a feeding technique. Our results show that both intercalating compounds increase significantly the frequency of sex-linked recessive lethals, but are unable to induce sex-chromosome loss in male germ cells under the conditions of testing. © 1985.

AB - To extend the data on the mutagenic effects of intercalating agents in Drosophila melanogaster, chloroquine and quinacrine were tested for the induction of genetic damage in D. melanogaster males. Sex-linked recessive lethals and sex-chromosome loss induction were studied following treatment of adult males using a feeding technique. Our results show that both intercalating compounds increase significantly the frequency of sex-linked recessive lethals, but are unable to induce sex-chromosome loss in male germ cells under the conditions of testing. © 1985.

U2 - https://doi.org/10.1016/0165-1218(85)90081-3

DO - https://doi.org/10.1016/0165-1218(85)90081-3

M3 - Article

SN - 0165-1218

VL - 158

SP - 177

EP - 180

JO - Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure

JF - Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure

ER -

Testing of chloroquine and quinacrine for mutagenicity in Drosophila melanogaster

Abstract

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