TY - JOUR
T1 - Ten-day sequential treatment for Helicobacter pylori eradication in clinical practice
AU - Sánchez-Delgado, Jordi
AU - Calvet, Xavier
AU - Bujanda, Luis
AU - Gisbert, Javier P.
AU - Titó, Llúcia
AU - Castro, Manuel
PY - 2008/9/1
Y1 - 2008/9/1
N2 - BACKGROUND: Cure rates of Helicobacter pylori infection with standard triple therapy are disappointingly low. A very effective, new sequential treatment schedule has recently been described. However, all studies published to date were performed in Italy; it is mandatory to confirm these results in other settings. AIM: To assess the cure rate and the acceptability of a new sequential treatment regimen through a pilot study. METHODS: A hundred and thirty-nine patients (60% men, mean age 49.6 ± 15.7 yr) were recruited from six centers. H. pylori status was assessed by histology, urease test or urea breath test. Sequential regime consisted of a 10-day treatment including a proton pump inhibitor (PPI) b.d. plus amoxicillin 1 g b.d. for the first 5 days, followed by a PPI b.d. clarithromycin 500 mg b.d. and metronidazole 500 mg b.d for the next 5 days. Eradication was determined 8 wk after the end of treatment by urea breath test or histology. Eradication rates were calculated both per protocol and by intention-to-treat. RESULTS: Eradication was achieved in 117 out of 129 patients who returned for a follow-up test. The intention-to-treat eradication rate was thus 84.2% (95%CI: 77%-90%) and the per-protocol cure rate 90.7% (95%CI: 84%-95%). The treatment was well tolerated. Only 14 patients complained of mild side effects. CONCLUSIONS: Sequential treatment seems highly effective for eradicating H. pylori. © 2008 by Am. Coll. of Gastroenterology.
AB - BACKGROUND: Cure rates of Helicobacter pylori infection with standard triple therapy are disappointingly low. A very effective, new sequential treatment schedule has recently been described. However, all studies published to date were performed in Italy; it is mandatory to confirm these results in other settings. AIM: To assess the cure rate and the acceptability of a new sequential treatment regimen through a pilot study. METHODS: A hundred and thirty-nine patients (60% men, mean age 49.6 ± 15.7 yr) were recruited from six centers. H. pylori status was assessed by histology, urease test or urea breath test. Sequential regime consisted of a 10-day treatment including a proton pump inhibitor (PPI) b.d. plus amoxicillin 1 g b.d. for the first 5 days, followed by a PPI b.d. clarithromycin 500 mg b.d. and metronidazole 500 mg b.d for the next 5 days. Eradication was determined 8 wk after the end of treatment by urea breath test or histology. Eradication rates were calculated both per protocol and by intention-to-treat. RESULTS: Eradication was achieved in 117 out of 129 patients who returned for a follow-up test. The intention-to-treat eradication rate was thus 84.2% (95%CI: 77%-90%) and the per-protocol cure rate 90.7% (95%CI: 84%-95%). The treatment was well tolerated. Only 14 patients complained of mild side effects. CONCLUSIONS: Sequential treatment seems highly effective for eradicating H. pylori. © 2008 by Am. Coll. of Gastroenterology.
U2 - 10.1111/j.1572-0241.2008.01924.x
DO - 10.1111/j.1572-0241.2008.01924.x
M3 - Article
SN - 0002-9270
VL - 103
SP - 2220
EP - 2223
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
ER -