Telomere dysfunction: A new player in radiation sensitivity

Anna Genescà, Marta Martín, Laura Latre, David Soler, Judit Pampalona, Laura Tusell

Research output: Contribution to journalReview articleResearchpeer-review

25 Citations (Scopus)

Abstract

Human individuals often exhibit important differences in their sensitivity to ionising radiation. Extensive literature links radiation sensitivity with impaired DNA repair which is due to a lack of correct functioning in many proteins involved in DNA-repair pathways and/or in DNA-damage checkpoint responses. Given that ionising radiation is an important and widespread diagnostic and therapeutic tool, it is important to investigate further those factors and mechanisms that underlie individual radiosensitivity. Recently, evidence is accumulating that telomere function may well be involved in cellular and organism responses to ionising radiation, broadening still further the currently complex and challenging scenario. © 2006 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)1172-1180
JournalBioEssays
Volume28
Issue number12
DOIs
Publication statusPublished - 1 Dec 2006

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