Teicoplanin for treating enterococcal infective endocarditis: A retrospective observational study from a referral centre in Spain

Laura Escolà-Vergé, Nuria Fernández-Hidalgo, Dolors Rodríguez-Pardo, Carlos Pigrau, Juan José González-López, Rosa Bartolomé, Benito Almirante

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4 Citations (Scopus)

Abstract

© 2018 Elsevier B.V. and International Society of Chemotherapy This study aimed to evaluate the effectiveness and safety of teicoplanin for treating enterococcal infective endocarditis (EIE). A retrospective analysis of a prospective cohort of definite EIE patients treated with teicoplanin in a Spanish referral centre (2000–2017) was performed. The primary outcome was mortality during treatment. Secondary outcomes were mortality during 3-month follow-up, adverse effects and relapse. A total of 22 patients received teicoplanin, 9 (40.9%) as first-line (8 Enterococcus faecium and 1 Enterococcus faecalis) and 13 (59.1%) as salvage therapy (13 E. faecalis). Median (IQR) age was 71.5 (58.3–78) years and Charlson comorbidity index was 4.5 (3–7). Five (22.7%) affected prosthetic valves. Median duration of treatment in survivors was 53 (42.5–61) days for antibiotics and 27 (17–41.5) days for teicoplanin [median dose 10 (10–10.8) mg/kg/day]. Reasons for teicoplanin use were resistance to β-lactams (40.9%), adverse events with previous regimens (31.8%) and outpatient parenteral antimicrobial therapy (OPAT) (27.3%). Teicoplanin was withdrawn due to adverse events in 2 patients (9.1%). Five patients (22.7%) died during treatment: four in the first-line (three with surgery indicated but not performed) and one in the salvage therapy group (surgery indicated but not performed). Two deaths (11.8%) occurred over the 3-month follow-up. There were no relapses during a median of 43.2 (22.1–69.1) months. Teicoplanin can be used as an alternative treatment for susceptible E. faecium IE and as a salvage therapy in selected patients with E. faecalis IE when adverse events develop with standard regimens or to allow OPAT.
Original languageEnglish
Pages (from-to)165-170
JournalInternational Journal of Antimicrobial Agents
Volume53
DOIs
Publication statusPublished - 1 Feb 2019

Keywords

  • Enterococcus faecalis
  • Enterococcus faecium
  • Infective endocarditis
  • Outpatient parenteral antimicrobial therapy
  • Teicoplanin

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