Tau phosphorylation and aggregation as a therapeutic target in tauopathies

Nahuai Badiola, Marc Suárez-Calvet, Alberto Lleó

    Research output: Contribution to journalArticleResearchpeer-review

    18 Citations (Scopus)

    Abstract

    Tauopathies are neurodegenerative diseases characterized by insoluble hyperphosphorylated deposits of the microtubule associated protein tau in the central nervous system. In these disorders, tau is believed to cause neurodegeneration and neuronal loss due to the loss of function of the normal protein, and/or the gain of toxic properties by generating multimeric species. The obstacles found in amyloid-based therapies in Alzheimer's disease, the most common tauopathy, have stimulated the search for alternative targets, including tau. In this article, we review the strategies aimed at reducing tau phosphorylation and aggregation as a target for drug intervention in tauopathies. © 2010 Bentham Science Publishers.
    Original languageEnglish
    Pages (from-to)727-740
    JournalCNS and Neurological Disorders - Drug Targets
    Volume9
    Issue number6
    DOIs
    Publication statusPublished - 1 Jan 2010

    Keywords

    • Alzheimer
    • Dementia
    • Frontotemporal dementia
    • Immunization
    • Kinase inhibitors
    • Tau
    • Tauopathies

    Fingerprint

    Dive into the research topics of 'Tau phosphorylation and aggregation as a therapeutic target in tauopathies'. Together they form a unique fingerprint.

    Cite this