Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury

Tiziano M. Scarabelli, Sofia Mariotto, Safwat Abdel-Azeim, Kazuo Shoji, Elena Darra, Anastasis Stephanou, Carol Chen-Scarabelli, Jean Didier Marechal, Richard Knight, Anna Ciampa, Louis Saravolatz, Alessandra Carcereri de Prati, Zhaokan Yuan, Elisabetta Cavalieri, Marta Menegazzi, David Latchman, Cosimo Pizza, David Perahia, Hisanori Suzuki

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Abstract

Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity. © 2008 Federation of European Biochemical Societies.
Original languageEnglish
Pages (from-to)531-541
JournalFEBS Letters
Volume583
Issue number3
DOIs
Publication statusPublished - 4 Feb 2009

Keywords

  • Antioxidant flavonoid
  • Apoptosis
  • Heart ischemia/reperfusion
  • STAT1
  • Surface plasmon resonance

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