Tannins from barks of Pinus caribaea protect Escherichia coli cells against DNA damage induced by γ-rays

J. L. Fuentes; M. Vernhe; E. B. Cuetara; A. Sánchez-Lamar; J. L. Santana; M. Llagostera

doi:10.1016/j.fitote.2005.11.014

Tannins from barks of Pinus caribaea protect Escherichia coli cells against DNA damage induced by γ-rays

J. L. Fuentes, M. Vernhe, E. B. Cuetara, A. Sánchez-Lamar, J. L. Santana, M. Llagostera

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

This work was aimed to evaluate genotoxicity and antigenotoxicity activity against γ-rays of a tannin fraction obtained from barks of Pinus caribaea, as well as to elucidate the antigenotoxic mechanisms involved in radioprotection by using different approaches as pre-, co- and post-irradiation cell treatments with plant extract. The tannin fraction was not genotoxic to Escherichia coli cells in experiments using different exposure times. This extract was antigenotoxic against γ-rays when the cells were pre- or co-treated with this extracts, but not during post-irradiation treatments, suggesting a possibly antigenotoxic action through free radical scavenging mechanisms. The results are discussed in relation to the chemopreventive and therapeutic potential of the studied plant species. © 2005 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	116-120
Journal	Fitoterapia
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/j.fitote.2005.11.014
Publication status	Published - 1 Feb 2006

Keywords

Escherichia coli
Pinus caribaea
SOS chromotest-radioprotectors
Tannins

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title = "Tannins from barks of Pinus caribaea protect Escherichia coli cells against DNA damage induced by γ-rays",

abstract = "This work was aimed to evaluate genotoxicity and antigenotoxicity activity against γ-rays of a tannin fraction obtained from barks of Pinus caribaea, as well as to elucidate the antigenotoxic mechanisms involved in radioprotection by using different approaches as pre-, co- and post-irradiation cell treatments with plant extract. The tannin fraction was not genotoxic to Escherichia coli cells in experiments using different exposure times. This extract was antigenotoxic against γ-rays when the cells were pre- or co-treated with this extracts, but not during post-irradiation treatments, suggesting a possibly antigenotoxic action through free radical scavenging mechanisms. The results are discussed in relation to the chemopreventive and therapeutic potential of the studied plant species. {\textcopyright} 2005 Elsevier B.V. All rights reserved.",

keywords = "Escherichia coli, Pinus caribaea, SOS chromotest-radioprotectors, Tannins",

author = "Fuentes, {J. L.} and M. Vernhe and Cuetara, {E. B.} and A. S{\'a}nchez-Lamar and Santana, {J. L.} and M. Llagostera",

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T1 - Tannins from barks of Pinus caribaea protect Escherichia coli cells against DNA damage induced by γ-rays

AU - Fuentes, J. L.

AU - Vernhe, M.

AU - Cuetara, E. B.

AU - Sánchez-Lamar, A.

AU - Santana, J. L.

AU - Llagostera, M.

PY - 2006/2/1

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N2 - This work was aimed to evaluate genotoxicity and antigenotoxicity activity against γ-rays of a tannin fraction obtained from barks of Pinus caribaea, as well as to elucidate the antigenotoxic mechanisms involved in radioprotection by using different approaches as pre-, co- and post-irradiation cell treatments with plant extract. The tannin fraction was not genotoxic to Escherichia coli cells in experiments using different exposure times. This extract was antigenotoxic against γ-rays when the cells were pre- or co-treated with this extracts, but not during post-irradiation treatments, suggesting a possibly antigenotoxic action through free radical scavenging mechanisms. The results are discussed in relation to the chemopreventive and therapeutic potential of the studied plant species. © 2005 Elsevier B.V. All rights reserved.

AB - This work was aimed to evaluate genotoxicity and antigenotoxicity activity against γ-rays of a tannin fraction obtained from barks of Pinus caribaea, as well as to elucidate the antigenotoxic mechanisms involved in radioprotection by using different approaches as pre-, co- and post-irradiation cell treatments with plant extract. The tannin fraction was not genotoxic to Escherichia coli cells in experiments using different exposure times. This extract was antigenotoxic against γ-rays when the cells were pre- or co-treated with this extracts, but not during post-irradiation treatments, suggesting a possibly antigenotoxic action through free radical scavenging mechanisms. The results are discussed in relation to the chemopreventive and therapeutic potential of the studied plant species. © 2005 Elsevier B.V. All rights reserved.

KW - Escherichia coli

KW - Pinus caribaea

KW - SOS chromotest-radioprotectors

KW - Tannins

U2 - 10.1016/j.fitote.2005.11.014

DO - 10.1016/j.fitote.2005.11.014

M3 - Article

VL - 77

SP - 116

EP - 120

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

IS - 2

ER -