Abstract
This work was aimed to evaluate genotoxicity and antigenotoxicity activity against γ-rays of a tannin fraction obtained from barks of Pinus caribaea, as well as to elucidate the antigenotoxic mechanisms involved in radioprotection by using different approaches as pre-, co- and post-irradiation cell treatments with plant extract. The tannin fraction was not genotoxic to Escherichia coli cells in experiments using different exposure times. This extract was antigenotoxic against γ-rays when the cells were pre- or co-treated with this extracts, but not during post-irradiation treatments, suggesting a possibly antigenotoxic action through free radical scavenging mechanisms. The results are discussed in relation to the chemopreventive and therapeutic potential of the studied plant species. © 2005 Elsevier B.V. All rights reserved.
Original language | English |
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Pages (from-to) | 116-120 |
Journal | Fitoterapia |
Volume | 77 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2006 |
Keywords
- Escherichia coli
- Pinus caribaea
- SOS chromotest-radioprotectors
- Tannins