The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decreased of dopaminergic neurotransmission. © 1990.
|Journal||Pharmacology Biochemistry and Behavior|
|Publication status||Published - 1 Jan 1990|
- Chronic treatment
- Food-reinforced behaviour
- Locomotor activity