T-maze performance in rats following chronic neuroleptic treatment

Sergi Ferré, Gemma Prat, Teresa Guix, Montserrat Gomá, Francesc Jané, Miquel Casas

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decreased of dopaminergic neurotransmission. © 1990.
Original languageEnglish
Pages (from-to)481-484
JournalPharmacology Biochemistry and Behavior
Volume35
DOIs
Publication statusPublished - 1 Jan 1990

Keywords

  • Chronic treatment
  • Food-reinforced behaviour
  • Haloperidol
  • Locomotor activity
  • rat

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