T-cell responses to the Mycobacterium tuberculosis-specific antigens in active tuberculosis patients at the beginning, during, and after antituberculosis treatment

Jose Domínguez, Malú De Souza-Galvão, Juan Ruiz-Manzano, Irene Latorre, Cristina Prat, Alicia Lacoma, Celia Milà, Maria Ángeles Jiménez, Silvia Blanco, José Maldonado, Neus Altet, Vicente Ausina

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48 Citations (Scopus)

Abstract

The objectives of the study were to assess the performance of the QuantiFERON-TB Gold In-Tube (QFN-G-IT) and the T-SPOT.TB tests in the immunodiagnosis of active tuberculosis (TB) in adult patients, and to study the T-cell interferon γ (IFN-γ) responses during treatment and in patients who have recovered after curative treatment and self-healed TB patients. When only analyzing patients included at the beginning of treatment, the sensitivity was 83.3% for T-SPOT.TB and 69.4% for QFN-G-IT. In contrast, when evaluating patients during treatment, the sensitivity of the T-SPOT.TB and QFN-G-IT decreased to 69.8% and 48.8%, respectively. The response to the specific antigens increased after finishing the treatment compared with the values during the treatment. The T-SPOT.TB was more sensitive in diagnosing active TB than the QFN-G-IT. The IFN-γ tests could be used as a complementary method in the diagnosis of active TB. © 2008 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)43-51
JournalDiagnostic Microbiology and Infectious Disease
Volume63
Issue number1
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • Active tuberculosis
  • Mycobacterium tuberculosis

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