TY - JOUR
T1 - T-cell responses to the Mycobacterium tuberculosis-specific antigens in active tuberculosis patients at the beginning, during, and after antituberculosis treatment
AU - Domínguez, Jose
AU - Souza-Galvão, Malú De
AU - Ruiz-Manzano, Juan
AU - Latorre, Irene
AU - Prat, Cristina
AU - Lacoma, Alicia
AU - Milà, Celia
AU - Jiménez, Maria Ángeles
AU - Blanco, Silvia
AU - Maldonado, José
AU - Altet, Neus
AU - Ausina, Vicente
PY - 2009/1/1
Y1 - 2009/1/1
N2 - The objectives of the study were to assess the performance of the QuantiFERON-TB Gold In-Tube (QFN-G-IT) and the T-SPOT.TB tests in the immunodiagnosis of active tuberculosis (TB) in adult patients, and to study the T-cell interferon γ (IFN-γ) responses during treatment and in patients who have recovered after curative treatment and self-healed TB patients. When only analyzing patients included at the beginning of treatment, the sensitivity was 83.3% for T-SPOT.TB and 69.4% for QFN-G-IT. In contrast, when evaluating patients during treatment, the sensitivity of the T-SPOT.TB and QFN-G-IT decreased to 69.8% and 48.8%, respectively. The response to the specific antigens increased after finishing the treatment compared with the values during the treatment. The T-SPOT.TB was more sensitive in diagnosing active TB than the QFN-G-IT. The IFN-γ tests could be used as a complementary method in the diagnosis of active TB. © 2008 Elsevier Inc. All rights reserved.
AB - The objectives of the study were to assess the performance of the QuantiFERON-TB Gold In-Tube (QFN-G-IT) and the T-SPOT.TB tests in the immunodiagnosis of active tuberculosis (TB) in adult patients, and to study the T-cell interferon γ (IFN-γ) responses during treatment and in patients who have recovered after curative treatment and self-healed TB patients. When only analyzing patients included at the beginning of treatment, the sensitivity was 83.3% for T-SPOT.TB and 69.4% for QFN-G-IT. In contrast, when evaluating patients during treatment, the sensitivity of the T-SPOT.TB and QFN-G-IT decreased to 69.8% and 48.8%, respectively. The response to the specific antigens increased after finishing the treatment compared with the values during the treatment. The T-SPOT.TB was more sensitive in diagnosing active TB than the QFN-G-IT. The IFN-γ tests could be used as a complementary method in the diagnosis of active TB. © 2008 Elsevier Inc. All rights reserved.
KW - Active tuberculosis
KW - Mycobacterium tuberculosis
U2 - 10.1016/j.diagmicrobio.2008.09.010
DO - 10.1016/j.diagmicrobio.2008.09.010
M3 - Article
SN - 0732-8893
VL - 63
SP - 43
EP - 51
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 1
ER -
