Systems analysis reveals complex biological processes during virus infection fate decisions

Jordi Argilaguet, Mireia Pedragosa, Anna Esteve-Codina, Graciela Riera, Enric Vidal, Cristina Peligero-Cruz, Valentina Casella, David Andreu, Tsuneyasu Kaisho, Gennady Bocharov, Burkhard Ludewig, Simon Heath, Andreas Meyerhans

    Research output: Contribution to journalArticleResearch

    12 Citations (Scopus)


    © 2019 Argilaguet et al. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see After six months, it is available under a Creative Commons License The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune response and chronic infection are poorly understood. Here, we characterized the host response to acute and chronic lymphocytic choriomeningitis virus (LCMV) infections by gene coexpression network analysis of time-resolved splenic transcriptomes. First, we found an early attenuation of inflammatory monocyte/macrophage prior to the onset of T cell exhaustion, and second, a critical role of the XCL1-XCR1 communication axis during the functional adaptation of the T cell response to the chronic infection state. These findings not only reveal an important feedback mechanism that couples T cell exhaustion with the maintenance of a lower level of effector T cell response but also suggest therapy options to better control virus levels during the chronic infection phase.
    Original languageEnglish
    Pages (from-to)907-919
    JournalGenome Research
    Publication statusPublished - 1 Jan 2019


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