Systemic Coronavirus-associated disease in the domestic ferret (Mustela putorius): Histopathologic and immunohistochemical characterization in three ferrets

C. Laprie, J. Duboy, J. Martinez

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2 Citations (Scopus)

Abstract

Background: A disease resembling feline infectious peritonitis (FIP) has been recognized recently in ferrets, mostly in United States and in Spain. This disease is due to a Group 1 Coronavirus, closely related to the ferret enteric Coronavirus. Objective: To demonstrate the viral origin of severe pyogranulomatous lymphoid and visceral lesions in three ferrets. Methods: Histopathology and immunohistochemistry of lesions received in our laboratory. Results: Severe pyogranulomatous inflammation was observed in the abdominal lymph nodes and in various organs. Positive labelling of Coronavirus antigen was demonstrated in macrophages in the pyogranulomatous lesions by immunohistochemistry. Conclusion: The three cases of severe pyogranulomatous disseminated inflammation were due to a Coronavirus, causing a systemic coronavirosis in ferret with a high similarity to FIP. © 2009 AFVAC.
Original languageEnglish
Pages (from-to)111-115
JournalPratique Medicale et Chirurgicale de l'Animal de Compagnie
Volume44
Issue number4
DOIs
Publication statusPublished - 1 Oct 2009

Keywords

  • Coronavirus
  • Feline coronavirosis
  • Ferret
  • Immunohistochemistry
  • Pyogranulomatous

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