Synthesis of sulfated bioactive peptides using immobilized arylsulfotransferase from Eubacterium sp

Bernard Delhom, Gregorio Alvaro, Gloria Caminal, Josep Lluís Torres, Pere Clapés

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

An arylsulfotransferase from Eubacterium sp. was immobilized on agarose gels by multipoint covalent attachment. The yield of immobilization was 80% with an activity of 11 UA/ml of derivative. After 19 days of incubation, the loss of activity of the derivative was 36%. The immobilized preparation was used to transfer selectively a sulfate group from p-nitrophenolsulfate to selected tyrosine containing biologically active peptides in 92-99% of yield.
Original languageEnglish
Pages (from-to)609-614
JournalBiotechnology Letters
Volume18
Issue number5
DOIs
Publication statusPublished - 1 Jan 1996

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