Synthesis of Novel Nucleoside Analogues Built on a Bicyclo[4.1.0]heptane Scaffold

Beatriz Domĺnguez-Pérez, Éric Ferrer, Marta Figueredo, Jean Didier Maréchal, Jan Balzarini, Ramon Alibés, Félix Busqué

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

© 2015 American Chemical Society. A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.
Original languageEnglish
Pages (from-to)9495-9505
JournalJournal of Organic Chemistry
Volume80
Issue number19
DOIs
Publication statusPublished - 2 Oct 2015

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