TY - JOUR
T1 - Synthesis of Novel Nucleoside Analogues Built on a Bicyclo[4.1.0]heptane Scaffold
AU - Domĺnguez-Pérez, Beatriz
AU - Ferrer, Éric
AU - Figueredo, Marta
AU - Maréchal, Jean Didier
AU - Balzarini, Jan
AU - Alibés, Ramon
AU - Busqué, Félix
PY - 2015/10/2
Y1 - 2015/10/2
N2 - © 2015 American Chemical Society. A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.
AB - © 2015 American Chemical Society. A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.
U2 - 10.1021/acs.joc.5b01413
DO - 10.1021/acs.joc.5b01413
M3 - Article
SN - 0022-3263
VL - 80
SP - 9495
EP - 9505
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 19
ER -