Synthesis of novel cyclopropyl carbocyclic nucleosides from (-)-(Z)-2,3-methanohomoserine

Joan Rifé, Rosa M. Ortuño

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

(matrix presented) The new cyclopropyl carbocyclic nucleosides 1 and 2 have been synthesized by following short and efficient routes starting from conveniently protected (-)-(Z)-methanohomoserine derivative 3. Both products 1 and 2 bear a quaternary stereogenic center and have opposite chirality. Moreover, the adenine derivative 2 belongs to a new class of cyclopropyl nucleoside showing an amino alcohol function at C-1 in addition to a methylene spacer between the base and the carbocyclic ring.
Original languageEnglish
Pages (from-to)1221-1223
JournalOrganic Letters
Volume1
Issue number8
Publication statusPublished - 21 Oct 1999

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