Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties

María Isabel Rodríguez-Franco; Isabel Dorronsoro; Ana Martínez; Concepción Pérez; Albert Badía; Josep E. Baños

doi:10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP118>3.0.CO;2-Q

Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties

María Isabel Rodríguez-Franco, Isabel Dorronsoro, Ana Martínez, Concepción Pérez, Albert Badía, Josep E. Baños

Department of Pharmacology, Therapeutics and Toxicology

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

The synthesis of new N-(4-pyridyl)-1-aminopyrazoles is described. Their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. The series derived from 3,5-dimethyl-1H-pyrazole showed moderate activities in both muscarinic and adrenergic receptor binding tests.

Original language	English
Pages (from-to)	118-122
Journal	Archiv der Pharmazie
Volume	333
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP118>3.0.CO;2-Q https://doi.org/10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP1
Publication status	Published - 1 May 2000

Keywords

1-Aminopyrazoles
4-aminopyridines
Adrenergic properties
Alzheimer's disease
Muscarinic properties

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Rodríguez-Franco, M. I., Dorronsoro, I., Martínez, A., Pérez, C., Badía, A., & Baños, J. E. (2000). Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties. Archiv der Pharmazie, 333(5), 118-122. https://doi.org/10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP118>3.0.CO;2-Q, https://doi.org/10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP1

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keywords = "1-Aminopyrazoles, 4-aminopyridines, Adrenergic properties, Alzheimer's disease, Muscarinic properties",

author = "Rodr{\'i}guez-Franco, \{Mar{\'i}a Isabel\} and Isabel Dorronsoro and Ana Mart{\'i}nez and Concepci{\'o}n P{\'e}rez and Albert Bad{\'i}a and Ba{\~n}os, \{Josep E.\}",

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Rodríguez-Franco, MI, Dorronsoro, I, Martínez, A, Pérez, C, Badía, A & Baños, JE 2000, 'Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties', Archiv der Pharmazie, vol. 333, no. 5, pp. 118-122. https://doi.org/10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP118>3.0.CO;2-Q, https://doi.org/10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP1

TY - JOUR

T1 - Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties

AU - Rodríguez-Franco, María Isabel

AU - Dorronsoro, Isabel

AU - Martínez, Ana

AU - Pérez, Concepción

AU - Badía, Albert

AU - Baños, Josep E.

PY - 2000/5/1

Y1 - 2000/5/1

N2 - The synthesis of new N-(4-pyridyl)-1-aminopyrazoles is described. Their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. The series derived from 3,5-dimethyl-1H-pyrazole showed moderate activities in both muscarinic and adrenergic receptor binding tests.

AB - The synthesis of new N-(4-pyridyl)-1-aminopyrazoles is described. Their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. The series derived from 3,5-dimethyl-1H-pyrazole showed moderate activities in both muscarinic and adrenergic receptor binding tests.

KW - 1-Aminopyrazoles

KW - 4-aminopyridines

KW - Adrenergic properties

KW - Alzheimer's disease

KW - Muscarinic properties

UR - https://www.scopus.com/pages/publications/0342858880

U2 - 10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP118>3.0.CO;2-Q

DO - 10.1002/(SICI)1521-4184(20005)333:5<118::AID-ARDP118>3.0.CO;2-Q

M3 - Article

SN - 0365-6233

VL - 333

SP - 118

EP - 122

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

IS - 5

ER -

Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties

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Keywords

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