Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties

Bruno Almeida, Jesús Joglar, María Jesús Luque Rojas, Juan Manuel Decara, Francisco Javier Bermúdez-Silva, Manuel Macias-González, Montserrat Fitó, Miguel Romero-Cuevas, Magí Farré, María Isabel Covas, Fernando Rodríguez De Fonseca, Rafael De La Torre

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

A series of fatty acid amides of 3,4-methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affinity for the CB1 receptor and/or PPAR-α; part of their biological activity may be caused by these double interactions. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Original languageEnglish
Pages (from-to)1781-1787
JournalChemMedChem
Volume5
Issue number10
DOIs
Publication statusPublished - 4 Oct 2010

Keywords

  • CB 1
  • Endocannabinoids
  • Obesity
  • PPAR-α
  • Receptors

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