Synthesis of apocarotenoids by acyclic cross metathesis and characterization as substrates for human retinaldehyde dehydrogenases

Marta Domínguez, Raquel Pequerul, Rosana Alvarez, Joan Giménez-Dejoz, Eszter Birta, Sergio Porté, Ralph Rühl, Xavier Parés, Jaume Farrés, Angel R. de Lera

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

© 2018 Elsevier Ltd A new synthesis of three apocarotenoids, namely 14′-apo-β-carotenal, 12′-apo-β-carotenal and 10′-apo-β-carotenal, has been achieved that is based on the acyclic cross-metathesis of the hexaene derived from retinal and the corresponding partners. These compounds can be enzymatically converted to their carboxylic acids by the human aldehyde dehydrogenases involved in retinaldehyde oxidation. Their kinetic parameters suggest that these enzymes might play a role in the physiological metabolism of apocarotenoids.
Original languageEnglish
Pages (from-to)2567-2574
JournalTetrahedron
Volume74
Issue number21
DOIs
Publication statusPublished - 24 May 2018

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