TY - JOUR
T1 - Synthesis of α-substituted and α,α-disubstituted α-amino acids by controlled mono- and dialkylation of ethyl N-diphenylmethyleneglycinate
AU - Ezquerra, Jesús
AU - Pedregal, Concepción
AU - Moreno-Mañas, Marcial
AU - Pleixats, Roser
AU - Roglans, Anna
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in the presence of powdered potassium hydroxide and a phase transfer catalysts gives, after hydrolysis, dialkylated glycine esters. © 1993.
AB - Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in the presence of powdered potassium hydroxide and a phase transfer catalysts gives, after hydrolysis, dialkylated glycine esters. © 1993.
U2 - 10.1016/S0040-4039(00)61378-3
DO - 10.1016/S0040-4039(00)61378-3
M3 - Article
VL - 34
SP - 8535
EP - 8538
IS - 52
ER -