Synthesis of α-substituted and α,α-disubstituted α-amino acids by controlled mono- and dialkylation of ethyl N-diphenylmethyleneglycinate

Jesús Ezquerra; Concepción Pedregal; Marcial Moreno-Mañas; Roser Pleixats; Anna Roglans

doi:10.1016/S0040-4039(00)61378-3

Synthesis of α-substituted and α,α-disubstituted α-amino acids by controlled mono- and dialkylation of ethyl N-diphenylmethyleneglycinate

Jesús Ezquerra, Concepción Pedregal, Marcial Moreno-Mañas, Roser Pleixats, Anna Roglans

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in the presence of powdered potassium hydroxide and a phase transfer catalysts gives, after hydrolysis, dialkylated glycine esters. © 1993.

Original language	English
Pages (from-to)	8535-8538
Journal	Tetrahedron Letters
Volume	34
Issue number	52
DOIs	https://doi.org/10.1016/S0040-4039(00)61378-3
Publication status	Published - 1 Jan 1993

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title = "Synthesis of α-substituted and α,α-disubstituted α-amino acids by controlled mono- and dialkylation of ethyl N-diphenylmethyleneglycinate",

abstract = "Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in the presence of powdered potassium hydroxide and a phase transfer catalysts gives, after hydrolysis, dialkylated glycine esters. {\textcopyright} 1993.",

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Synthesis of α-substituted and α,α-disubstituted α-amino acids by controlled mono- and dialkylation of ethyl N-diphenylmethyleneglycinate. / Ezquerra, Jesús; Pedregal, Concepción; Moreno-Mañas, Marcial; Pleixats, Roser; Roglans, Anna.

In: Tetrahedron Letters, Vol. 34, No. 52, 01.01.1993, p. 8535-8538.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Synthesis of α-substituted and α,α-disubstituted α-amino acids by controlled mono- and dialkylation of ethyl N-diphenylmethyleneglycinate

AU - Ezquerra, Jesús

AU - Pedregal, Concepción

AU - Moreno-Mañas, Marcial

AU - Pleixats, Roser

AU - Roglans, Anna

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in the presence of powdered potassium hydroxide and a phase transfer catalysts gives, after hydrolysis, dialkylated glycine esters. © 1993.

AB - Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in the presence of powdered potassium hydroxide and a phase transfer catalysts gives, after hydrolysis, dialkylated glycine esters. © 1993.

U2 - 10.1016/S0040-4039(00)61378-3

DO - 10.1016/S0040-4039(00)61378-3

M3 - Article

VL - 34

SP - 8535

EP - 8538

IS - 52

ER -