Synthesis, culture medium stability, and in vitro and in vivo zebrafish embryo toxicity of metal-organic framework nanoparticles

Angels Ruyra, Amirali Yazdi, Jordi Espín, Arnau Carné-Sánchez, Nerea Roher, Julia Lorenzo, Inhar Imaz, Daniel Maspoch

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Abstract

© 2015 Wiley-VCH Verlag GmbH & Co. KGaA. Metal-organic frameworks (MOFs) are among the most attractive porous materials available today. They have garnered much attention for their potential utility in many different areas such as gas storage, separation, catalysis, and biomedicine. However, very little is known about the possible health or environmental risks of these materials. Here, the results of toxicity studies on sixteen representative uncoated MOF nanoparticles (nanoMOFs), which were assessed for cytotoxicity to HepG2 and MCF7 cells in vitro, and for toxicity to zebrafish embryos in vivo, are reported. Interestingly, there is a strong correlation between their in vitro toxicity and their in vivo toxicity. NanoMOFs were ranked according to their respective in vivo toxicity (in terms of the amount and severity of phenotypic changes observed in the treated zebrafish embryos), which varied widely. Altogether these results show different levels of toxicity of these materials; however, leaching of solubilized metal ions plays a main role.
Original languageEnglish
Pages (from-to)2508-2518
JournalChemistry - A European Journal
Volume21
Issue number6
DOIs
Publication statusPublished - 2 Feb 2015

Keywords

  • Metal-organic frameworks
  • Microporous materials
  • Nanoparticles
  • Toxicology
  • Zebrafish

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