TY - JOUR
T1 - Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9
AU - Lobo, Gricela
AU - Monasterios, Melina
AU - Rodrigues, Juan
AU - Gamboa, Neira
AU - Capparelli, Mario V.
AU - Martínez-Cuevas, Javier
AU - Lein, Michael
AU - Jung, Klaus
AU - Abramjuk, Claudia
AU - Charris, Jaime
PY - 2015/5/26
Y1 - 2015/5/26
N2 - © 2015 Elsevier Masson SAS. All rights reserved. A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both cell lines in a time and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on clonogenic possibly by inhibition of MMP-9 activity. Molecular docking of 7q and 6k into MMP-9 human active site was also performed to determine the probable binding mode.
AB - © 2015 Elsevier Masson SAS. All rights reserved. A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both cell lines in a time and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on clonogenic possibly by inhibition of MMP-9 activity. Molecular docking of 7q and 6k into MMP-9 human active site was also performed to determine the probable binding mode.
KW - Cancer
KW - Crystal
KW - Indeno
KW - MMP-9
KW - Prostate
KW - Regiospecif
U2 - 10.1016/j.ejmech.2015.04.023
DO - 10.1016/j.ejmech.2015.04.023
M3 - Article
VL - 96
SP - 281
EP - 295
ER -