Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine

Alberto Martínez; Julia Lorenzo; Maria J. Prieto; Rafael De Llorens; Mercè Font-Bardia; Xavier Solans; Francesc X. Avilés; Virtudes Moreno

doi:https://doi.org/10.1002/cbic.200500108

Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine

Alberto Martínez, Julia Lorenzo, Maria J. Prieto, Rafael De Llorens, Mercè Font-Bardia, Xavier Solans, Francesc X. Avilés, Virtudes Moreno

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

The synthesis and chemical characterization of two new trans platinum complexes, trans-[PtCl2NH3(4-hydroxymethylpyridine)] (1) and trans-[PtCl4NH3(4-hydroxymethylpyridine)] (2) are described. Their ability to interact with 5′-GMP by themselves and in the presence of reducing agents in the case of trans-[PtCl4NH 3(4-hydroxymethylpyridine)] were tested. Circular dichroism, electrophoretic mobility in agarose gel, and atomic force microscopy studies showed that the interaction of complex 1 with DNA is stronger than that of complex 2. Cytotoxicity tests against HL-60 tumor cells also showed higher activity for trans-[PtCl2NH3(4-hydroxymethylpyridine)] than for trans-[PtCl4NH3(4-hydroxymethylpyridine)]. Complex 1 presents similar behavior to cisplatin, but with a lower IC 50 at 24 h. Complex 1 also showed high apoptosis induction. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	2068-2077
Journal	ChemBioChem
Volume	6
DOIs	https://doi.org/10.1002/cbic.200500108
Publication status	Published - 1 Nov 2005

Keywords

Ab initio calculations
Antitumor agents
Apoptosis
Bioinorganic chemistry
DNA
Platinum

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@article{8572a5a8c02c4ff4a3fd4b21c46684e8,

title = "Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine",

abstract = "The synthesis and chemical characterization of two new trans platinum complexes, trans-[PtCl2NH3(4-hydroxymethylpyridine)] (1) and trans-[PtCl4NH3(4-hydroxymethylpyridine)] (2) are described. Their ability to interact with 5′-GMP by themselves and in the presence of reducing agents in the case of trans-[PtCl4NH 3(4-hydroxymethylpyridine)] were tested. Circular dichroism, electrophoretic mobility in agarose gel, and atomic force microscopy studies showed that the interaction of complex 1 with DNA is stronger than that of complex 2. Cytotoxicity tests against HL-60 tumor cells also showed higher activity for trans-[PtCl2NH3(4-hydroxymethylpyridine)] than for trans-[PtCl4NH3(4-hydroxymethylpyridine)]. Complex 1 presents similar behavior to cisplatin, but with a lower IC 50 at 24 h. Complex 1 also showed high apoptosis induction. {\textcopyright} 2005 Wiley-VCH Verlag GmbH & Co. KGaA.",

keywords = "Ab initio calculations, Antitumor agents, Apoptosis, Bioinorganic chemistry, DNA, Platinum",

author = "Alberto Mart{\'i}nez and Julia Lorenzo and Prieto, {Maria J.} and {De Llorens}, Rafael and Merc{\`e} Font-Bardia and Xavier Solans and Avil{\'e}s, {Francesc X.} and Virtudes Moreno",

year = "2005",

month = nov,

day = "1",

doi = "https://doi.org/10.1002/cbic.200500108",

language = "English",

volume = "6",

pages = "2068--2077",

journal = "ChemBioChem",

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TY - JOUR

T1 - Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine

AU - Martínez, Alberto

AU - Lorenzo, Julia

AU - Prieto, Maria J.

AU - De Llorens, Rafael

AU - Font-Bardia, Mercè

AU - Solans, Xavier

AU - Avilés, Francesc X.

AU - Moreno, Virtudes

PY - 2005/11/1

Y1 - 2005/11/1

N2 - The synthesis and chemical characterization of two new trans platinum complexes, trans-[PtCl2NH3(4-hydroxymethylpyridine)] (1) and trans-[PtCl4NH3(4-hydroxymethylpyridine)] (2) are described. Their ability to interact with 5′-GMP by themselves and in the presence of reducing agents in the case of trans-[PtCl4NH 3(4-hydroxymethylpyridine)] were tested. Circular dichroism, electrophoretic mobility in agarose gel, and atomic force microscopy studies showed that the interaction of complex 1 with DNA is stronger than that of complex 2. Cytotoxicity tests against HL-60 tumor cells also showed higher activity for trans-[PtCl2NH3(4-hydroxymethylpyridine)] than for trans-[PtCl4NH3(4-hydroxymethylpyridine)]. Complex 1 presents similar behavior to cisplatin, but with a lower IC 50 at 24 h. Complex 1 also showed high apoptosis induction. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - The synthesis and chemical characterization of two new trans platinum complexes, trans-[PtCl2NH3(4-hydroxymethylpyridine)] (1) and trans-[PtCl4NH3(4-hydroxymethylpyridine)] (2) are described. Their ability to interact with 5′-GMP by themselves and in the presence of reducing agents in the case of trans-[PtCl4NH 3(4-hydroxymethylpyridine)] were tested. Circular dichroism, electrophoretic mobility in agarose gel, and atomic force microscopy studies showed that the interaction of complex 1 with DNA is stronger than that of complex 2. Cytotoxicity tests against HL-60 tumor cells also showed higher activity for trans-[PtCl2NH3(4-hydroxymethylpyridine)] than for trans-[PtCl4NH3(4-hydroxymethylpyridine)]. Complex 1 presents similar behavior to cisplatin, but with a lower IC 50 at 24 h. Complex 1 also showed high apoptosis induction. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Ab initio calculations

KW - Antitumor agents

KW - Apoptosis

KW - Bioinorganic chemistry

KW - DNA

KW - Platinum

U2 - https://doi.org/10.1002/cbic.200500108

DO - https://doi.org/10.1002/cbic.200500108

M3 - Article

VL - 6

SP - 2068

EP - 2077

JO - ChemBioChem

JF - ChemBioChem

SN - 1439-4227

ER -

Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine

Abstract

Keywords

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