Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine

Alberto Martínez, Julia Lorenzo, Maria J. Prieto, Rafael De Llorens, Mercè Font-Bardia, Xavier Solans, Francesc X. Avilés, Virtudes Moreno

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17 Citations (Scopus)

Abstract

The synthesis and chemical characterization of two new trans platinum complexes, trans-[PtCl2NH3(4-hydroxymethylpyridine)] (1) and trans-[PtCl4NH3(4-hydroxymethylpyridine)] (2) are described. Their ability to interact with 5′-GMP by themselves and in the presence of reducing agents in the case of trans-[PtCl4NH 3(4-hydroxymethylpyridine)] were tested. Circular dichroism, electrophoretic mobility in agarose gel, and atomic force microscopy studies showed that the interaction of complex 1 with DNA is stronger than that of complex 2. Cytotoxicity tests against HL-60 tumor cells also showed higher activity for trans-[PtCl2NH3(4-hydroxymethylpyridine)] than for trans-[PtCl4NH3(4-hydroxymethylpyridine)]. Complex 1 presents similar behavior to cisplatin, but with a lower IC 50 at 24 h. Complex 1 also showed high apoptosis induction. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
Original languageEnglish
Pages (from-to)2068-2077
JournalChemBioChem
Volume6
DOIs
Publication statusPublished - 1 Nov 2005

Keywords

  • Ab initio calculations
  • Antitumor agents
  • Apoptosis
  • Bioinorganic chemistry
  • DNA
  • Platinum

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