Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. Naturally-occurring, halogenated furanones isolated from marine algae have proven to be effective biofilm inhibitors in several bacterial species. In this work, we report the synthesis of a library of novel furanones and their subsequent evaluation as biofilm inhibitors in several opportunistic human pathogens including S. enterica, S. aureus, E. coli, S. maltophilia, P. aeruginosa and C. albicans. A number of the most potent compounds were subjected to further analysis by confocal laser-scanning microscopy for their effects on P. aeruginosa and C. albicans biofilms individually, in addition to mixed polymicrobial biofilms. Lastly, we investigated the impact of a promising candidate on survival rates in vivo using a Galleria mellonella model.

Original languageEnglish
Article number114678
Number of pages16
Publication statusPublished - 15 Nov 2022


  • Biofilms
  • Candida albicans
  • Escherichia coli
  • Furanones
  • Pseudomonas aeruginosa
  • Quorum sensing
  • Salmonella enterica
  • Staphylococcus aureus
  • Stenotrophomonas maltophilia


Dive into the research topics of 'Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens'. Together they form a unique fingerprint.

Cite this