Synthesis and activity studies in vitro and in vivo of a new series of malonato-platinum(II) complexes containing sulfide and phosphine ligands

F. Sampedro, AM Molins-Pujol, JI Ruiz, P. Santaló, J. Bonal, M. Pueyo, M. Llagostera, F. Sánchez-Ferrando

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4 Citations (Scopus)

Abstract

Three new malonato platinum(II) complexes containing P and S ligands are reported. In in vitro tests, all three compounds showed damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using leukemia L1210° cells on mice BDF, show that two of these compounds are potentially active. © 1992.
Original languageEnglish
Pages (from-to)611-614
JournalEuropean Journal of Medicinal Chemistry
Volume27
Issue number6
DOIs
Publication statusPublished - 1 Jan 1992

Keywords

  • antitumoral activity
  • cancer treatment
  • L1210° leukemia
  • malonate
  • platinum(II)-complex
  • platinum(II)-DNA damage

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