Three new malonato platinum(II) complexes containing P and S ligands are reported. In in vitro tests, all three compounds showed damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using leukemia L1210° cells on mice BDF, show that two of these compounds are potentially active. © 1992.
|Journal||European Journal of Medicinal Chemistry|
|Publication status||Published - 1 Jan 1992|
- antitumoral activity
- cancer treatment
- L1210° leukemia
- platinum(II)-DNA damage