Synovial fluid D-dimer concentration in horses with osteochondritis dissecans and osteoarthritis

Marta Prades Robles, Luis Monreal Bosch, Maria Angeles Delgado Jorde, Thais Ribera, J. Ríos

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6 Citations (Scopus)

Abstract

Objective: To assess the synovial fibrinolytic pathway activation in adult horses with developmental and degenerative arthropathies such as osteochondritis dissecans (OCD) and osteoarthritis (OA) by measuring synovial D-dimer concentrations. Methods: Prospective observational clinical study of horses admitted for OCD or OA. Synovial fluid was collected during lameness examination or prior to the surgical procedure, and D-dimer concentration and routine synovial fluid analysis were performed. Results: Fifty-eight horses (14 with OCD, 10 with OA and 34 controls) were included in this study. Synovial D-dimer concentrations of horses with OCD and OA were both higher when compared with controls, but were only significantly different in horses with OCD (p = 0.005). However, no statistical differences were observed when comparing synovial D-dimer concentrations from the OCD horses with the OA-affected horses (p = 0.444).Clinical significance: Activation of coagulation and fibrinolysis play a role in the pathophysiology of equine OCD and OA. © Schattauer 2013.
Original languageEnglish
Pages (from-to)54-60
JournalVeterinary and Comparative Orthopaedics and Traumatology
Volume26
Issue number1
DOIs
Publication statusPublished - 8 Apr 2013

Keywords

  • Horse
  • Osteoarthritis
  • Osteochondritis dissecans
  • Synovial D-dimer concentration
  • Synovial fibrinolytic activity

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