Swelling of the bronchial mucose and quickness of onset in acute asthma

Jesús Bellido-Casado, Vicente Plaza, José Belda, Cecilia Martínez-Brú, Montserrat Torrejón, Joaquín Sanchis

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BACKGROUND AND OBJECTIVE: The plasma protein leackage produced in the bronchial mucose of patients with acute asthma might be associated to the quickness of the onset exacerbation. The aim of this study was to study this association. PATIENTS AND METHOD: 22 patients with acute asthma were recruited, and the magnitude of plasma protein leackage was meassured by the concentrations of albumin and α2-macroglobulin in sputum. RESULTS: Days of onset in acute asthma correlated negatively with albumin sputum concentration (r = -0.563; p = 0.006), α2-macroglobulin sputum concentration (r = -0.603; p = 0.003), and related relative coefficients of albumin sputum/serum (r = -0.538; p = 0.01) and α2-macroglobulin sputum/serum (r = -0.514; p = 0.014). When the sample was divided by the following daily cutoff: ≤ 4, patients suffering from a shorter onset of acute asthma showed a higher concentration of α2-macroglobulin in sputum: mean (standard deviation) of 14.4 (18) versus 5.3 (5.4) (p = 0.028). CONCLUSIONS: Plasma protein leackage seems to play an important role in the inflammatory pathogenesis of asthma exacerbation. The quicker onset of asthma the more plasma protein extravasation to the bronchial lumen.
Original languageEnglish
Pages (from-to)451-453
JournalMedicina Clinica
Publication statusPublished - 30 Sep 2006


  • Acute asthma
  • Albumin
  • Bronchial swelling
  • Induced sputum
  • Near-fatal asthma
  • α- macroglobulin 2


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