Sustained response to Rituximab in anti-AChR and anti-MuSK positive Myasthenia Gravis patients

Isabel Illa, Jordi Diaz-Manera, Ricard Rojas-Garcia, Jesus Pradas, Antonio Rey, Rafael Blesa, Candido Juarez, Eduard Gallardo

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95 Citations (Scopus)

Abstract

We report the results of treatment with Rituximab in six severe, non-responder MG patients. We treated three AChR + MG and three MuSK + MG patients, representing 2% and 20% of the respective groups of our series. Patients were assessed according to the Myasthenia Gravis Foundation of America (MGFA) recommendations. Antibody titers to AChR and MuSK, Ig levels, and IgG subclasses, were tested before treatment and during a follow-up of 9-22 months. All patients, one class V and five class IVB, improved dramatically, with no side effects. Antibody titers declined in all patients (p = 0.006). The decline was significantly better in MuSK + MG patients at 9 months (p = 0.046) and correlated with a more sustained clinical improvement. We did not find any significant changes in IgG4 that could explain the different outcome observed between these two groups. © 2008 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)90-94
JournalJournal of Neuroimmunology
Volume201-202
Issue numberC
DOIs
Publication statusPublished - 15 Sep 2008

Keywords

  • AChR antibodies
  • MuSK antibodies
  • Myasthenia Gravis treatment
  • Rituximab

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