Sustained release of liposome-encapsulated enrofloxacin after intramuscular administration in rabbits

A. Cabanes, F. Reig, J. M. Garcia Anton, M. Arboix

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    16 Citations (Scopus)

    Abstract

    Enrofloxacin was encapsulated in multilamellar liposomes composed of phosphatidylcholine and cholesterol (molar ratio, 1:1), and its potential use as sustained release formulation was evaluated. The encapsulated drug was administered IM to rabbits (n = 6). Results indicated that absorption rate was slow, compared with previous studies; additionally, peak concentration was lower (0.5 ± 0.1 μg/ml), and the time to peak concentration was considerably longer for liposome-encapsulated enrofloxacin (1.5 ± 1.08 hours) than for unencapsulated drug. Apparent elimination half-life of drug in the body was significantly (P < 0.05) increased (4.05 ± 1.08 hours) when it was administered encapsulated in liposomes. Large-size liposomes containing enrofloxacin administered IM to rabbits gave sustained drug release from the injection site, providing therapeutic and prolonged plasma concentrations of drug in the body.
    Original languageEnglish
    Pages (from-to)1498-1501
    JournalAmerican Journal of Veterinary Research
    Volume56
    Issue number11
    Publication statusPublished - 1 Jan 1995

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