Sustainable photoinduced decarboxylative chlorination mediated by halogen atom transfer

Guillaume Levitre, Albert Granados, Gary A. Molander

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Chlorinated organic backbones constitute important components in existing biologically active chemicals, and they are extraordinary useful intermediates in organic synthesis. Herein, an operationally simple and sustainable halodecarboxylation protocol via halogen-atom transfer (XAT) as a key step is presented. The method merges a metal-free photoredox system with (diacetoxyiodo)benzene (PIDA) as a hypervalent iodine reagent using 1,2-dihaloethanes as halogen sources to afford haloalkanes in an efficient manner. The sustainability of this protocol is highlighted by an important waste recovery protocol as well as by atom economy and carbon efficiency parameters.
Original languageEnglish
Pages (from-to)560-565
Number of pages6
JournalGreen Chemistry
Volume25
Issue number2
DOIs
Publication statusPublished - 21 Jan 2023

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