Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment

Michael Escobar, Oriol Careta, Nora Fernández Navas, Aleksandra Bartkowska, Ludovico Andrea Alberta, Jordina Fornell, Pau Solsona, Thomas Gemming, Annett Gebert, Elena Ibáñez, Andreu Blanquer, Carme Nogués, Jordi Sort, Eva Pellicer

Research output: Contribution to journalArticleResearchpeer-review


Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic elements, namely Ti-18Mo-6Nb-5Ta (wt%), has been fabricated by arc melting. The resulting single β-phase alloy shows improved mechanical properties (Young’s modulus and hardness) and similar corrosion behavior in simulated body fluid when compared with commercial Ti-6Al-4V. To increase the cell proliferation capability of the new biomaterial, the surface of Ti-18Mo-6Nb-5Ta was modified by electrodepositing calcium phosphate (CaP) ceramic layers. Coatings with a Ca/P ratio of 1.47 were obtained at pulse current densities, −jc, of 1.8–8.2 mA/cm2, followed by 48 h of NaOH post-treatment. The thickness of the coatings has been measured by scanning electron microscopy from an ion beam cut, resulting in an average thickness of about 5 μm. Finally, cytocompatibility and cell adhesion have been evaluated using the osteosarcoma cell line Saos-2, demonstrating good biocompatibility and enhanced cell proliferation on the CaP-modified Ti-18Mo-6Nb-5Ta material compared with the bare alloy, even outperforming their CaP-modified Ti-6-Al-4V counterparts.
Original languageEnglish
Article number94
Number of pages20
JournalJournal of Functional Biomaterials
Issue number2
Early online date9 Feb 2023
Publication statusPublished - 9 Feb 2023


  • Titanium alloy
  • Electrodeposition
  • Ceramic coating
  • Indentation
  • Corrosion resistance
  • Cell proliferation
  • indentation
  • cell proliferation
  • ceramic coating
  • titanium alloy
  • electrodeposition
  • corrosion resistance


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