Surface fractals in liposome aggregation

Sándalo Roldán-Vargas, Ramon Barnadas-Rodríguez, Manuel Quesada-Pérez, Joan Estelrich, José Callejas-Fernández

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24 Citations (Scopus)

Abstract

In this work, the aggregation of charged liposomes induced by magnesium is investigated. Static and dynamic light scattering, Fourier-transform infrared spectroscopy, and cryotransmission electron microscopy are used as experimental techniques. In particular, multiple intracluster scattering is reduced to a negligible amount using a cross-correlation light scattering scheme. The analysis of the cluster structure, probed by means of static light scattering, reveals an evolution from surface fractals to mass fractals with increasing magnesium concentration. Cryotransmission electron microscopy micrographs of the aggregates are consistent with this interpretation. In addition, a comparative analysis of these results with those previously reported in the presence of calcium suggests that the different hydration energy between lipid vesicles when these divalent cations are present plays a fundamental role in the cluster morphology. This suggestion is also supported by infrared spectroscopy data. The kinetics of the aggregation processes is also analyzed through the time evolution of the mean diffusion coefficient of the aggregates. © 2009 The American Physical Society.
Original languageEnglish
Article number011905
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume79
Issue number1
DOIs
Publication statusPublished - 5 Jan 2009

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