Abstract
© 2014, European Society of Radiology. Objectives: To assess whether 1H-MRS may be useful to reinforce the radiological suspicion of PCNSL.Methods: In this retrospective study, we included 546 patients with untreated brain tumours in which single-voxel spectroscopy at TE 30 ms and 136 ms had been performed. The patients were split into two subgroups: “training set” and “test set.” Differences between PCNSL and five other types of intracranial tumours were assessed in the test set of patients using the Mann-Whitney U nonparametric test and cut-off values for pair-wise comparisons defined by constructing receiver operating characteristic curves. These thresholds were used to construct classifiers for binary comparison between PCNSL and non-PCNSL. The performance of the obtained classifiers was assessed in the independent test set of patients.Results: Significant differences were found between PCNSL and the other groups evaluated. All bilateral comparisons performed in the test set obtained accuracy values above 70 % (71–89 %). Lipids were found to be useful to discriminate between PCNSL and glioblastoma/metastasis at short TE. Myo-inositol resonance was found to be very consistent for discriminating between PCNSL and astrocytomas at short TE.Conclusions: 1H-MRS is useful to reinforce diagnostic suspicion of PCNSL on MRI.
Original language | English |
---|---|
Pages (from-to) | 2895-2905 |
Journal | European Radiology |
Volume | 24 |
DOIs | |
Publication status | Published - 1 Jan 2014 |
Keywords
- Brain neoplasms
- Diagnosis
- Lymphoma
- Magnetic resonance
- Spectroscopy