Sulfide and phosphine ligands in carboplatin analogs

F. Sampedro, AM Molins-Pujol, J. Bonal, J. Barbé, S. Garrido, M. Pueyo, M. Llagostera, F. Sánchez-Ferrando

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7 Citations (Scopus)

Abstract

Three new carboplatin analogs containing P and S ligands are reported. A new synthesis of the intermediate cis-dichlorobis{tris(hydroxymethyl)phosphine}platinum(II) is described. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using Leukemia L1210° cells on mice BDF1 show that these compounds are potentially active. © 1991.
Original languageEnglish
Pages (from-to)539-543
JournalEuropean Journal of Medicinal Chemistry
Volume26
Issue number5
DOIs
Publication statusPublished - 1 Jan 1991

Keywords

  • antitumoral activity
  • cancer treatment
  • cyclobutanedicarboxylato
  • L leukemia 1210°
  • platinum(II)-complexes
  • platinum(II)-DNA damage

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