Abstract
Three new carboplatin analogs containing P and S ligands are reported. A new synthesis of the intermediate cis-dichlorobis{tris(hydroxymethyl)phosphine}platinum(II) is described. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using Leukemia L1210° cells on mice BDF1 show that these compounds are potentially active. © 1991.
Original language | English |
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Pages (from-to) | 539-543 |
Journal | European Journal of Medicinal Chemistry |
Volume | 26 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Jan 1991 |
Keywords
- antitumoral activity
- cancer treatment
- cyclobutanedicarboxylato
- L leukemia 1210°
- platinum(II)-complexes
- platinum(II)-DNA damage