Sulfide and phosphine ligands in carboplatin analogs

F. Sampedro; AM Molins-Pujol; J. Bonal; J. Barbé; S. Garrido; M. Pueyo; M. Llagostera; F. Sánchez-Ferrando

doi:10.1016/0223-5234(91)90150-L

Sulfide and phosphine ligands in carboplatin analogs

F. Sampedro, AM Molins-Pujol, J. Bonal, J. Barbé, S. Garrido, M. Pueyo, M. Llagostera, F. Sánchez-Ferrando

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Three new carboplatin analogs containing P and S ligands are reported. A new synthesis of the intermediate cis-dichlorobis{tris(hydroxymethyl)phosphine}platinum(II) is described. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using Leukemia L1210° cells on mice BDF1 show that these compounds are potentially active. © 1991.

Original language	English
Pages (from-to)	539-543
Journal	European Journal of Medicinal Chemistry
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/0223-5234(91)90150-L
Publication status	Published - 1 Jan 1991

Keywords

antitumoral activity
cancer treatment
cyclobutanedicarboxylato
L leukemia 1210°
platinum(II)-complexes
platinum(II)-DNA damage

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title = "Sulfide and phosphine ligands in carboplatin analogs",

abstract = "Three new carboplatin analogs containing P and S ligands are reported. A new synthesis of the intermediate cis-dichlorobis{tris(hydroxymethyl)phosphine}platinum(II) is described. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using Leukemia L1210° cells on mice BDF1 show that these compounds are potentially active. {\textcopyright} 1991.",

keywords = "antitumoral activity, cancer treatment, cyclobutanedicarboxylato, L leukemia 1210°, platinum(II)-complexes, platinum(II)-DNA damage",

author = "F. Sampedro and AM Molins-Pujol and J. Bonal and J. Barb{\'e} and S. Garrido and M. Pueyo and M. Llagostera and F. S{\'a}nchez-Ferrando",

year = "1991",

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T1 - Sulfide and phosphine ligands in carboplatin analogs

AU - Sampedro, F.

AU - Molins-Pujol, AM

AU - Bonal, J.

AU - Barbé, J.

AU - Garrido, S.

AU - Pueyo, M.

AU - Llagostera, M.

AU - Sánchez-Ferrando, F.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Three new carboplatin analogs containing P and S ligands are reported. A new synthesis of the intermediate cis-dichlorobis{tris(hydroxymethyl)phosphine}platinum(II) is described. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using Leukemia L1210° cells on mice BDF1 show that these compounds are potentially active. © 1991.

AB - Three new carboplatin analogs containing P and S ligands are reported. A new synthesis of the intermediate cis-dichlorobis{tris(hydroxymethyl)phosphine}platinum(II) is described. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using Leukemia L1210° cells on mice BDF1 show that these compounds are potentially active. © 1991.

KW - antitumoral activity

KW - cancer treatment

KW - cyclobutanedicarboxylato

KW - L leukemia 1210°

KW - platinum(II)-complexes

KW - platinum(II)-DNA damage

U2 - 10.1016/0223-5234(91)90150-L

DO - 10.1016/0223-5234(91)90150-L

M3 - Article

VL - 26

SP - 539

EP - 543

IS - 5

ER -