TY - JOUR
T1 - Successful use of cinacalcet to treat parathyroid-related hypercalcemia in two pediatric patients
AU - Moreno Galdo, Antonio Jose
AU - Mogas Viñals, Eduard
AU - Campos Martorell, Ariadna
AU - Clemente Leon, Maria
AU - Castaño, L.
AU - Yeste Fernandez, Diego
AU - Carrascosa Lezcano, Antonio
PY - 2018
Y1 - 2018
N2 - Two pediatric patients with different causes of hyperparathyroidism are reported. First patient is a 13-year-old male with severe hypercalcemia due to left upper parathyroid gland adenoma. After successful surgery, calcium and phosphate levels normalized, but parathormone levels remained elevated. Further studies revealed a second adenoma in the right gland. The second patient is a 13-year-old female with uncommon hypercalcemia symptoms. Presence of pathogenic calcium-sensing receptor gene (CASR) mutation was found, resulting in diagnosis of symptomatic familial hypocalciuric hypercalcemia. Cinacalcet, a calcium-sensing agent that increases the sensitivity of the CASR, was used in both patients with successful results.
AB - Two pediatric patients with different causes of hyperparathyroidism are reported. First patient is a 13-year-old male with severe hypercalcemia due to left upper parathyroid gland adenoma. After successful surgery, calcium and phosphate levels normalized, but parathormone levels remained elevated. Further studies revealed a second adenoma in the right gland. The second patient is a 13-year-old female with uncommon hypercalcemia symptoms. Presence of pathogenic calcium-sensing receptor gene (CASR) mutation was found, resulting in diagnosis of symptomatic familial hypocalciuric hypercalcemia. Cinacalcet, a calcium-sensing agent that increases the sensitivity of the CASR, was used in both patients with successful results.
UR - http://europepmc.org/articles/PMC5993061
U2 - 10.1530/EDM-18-0009
DO - 10.1530/EDM-18-0009
M3 - Article
SN - 2052-0573
JO - Endocrinology, Diabetes and Metabolism Case Reports
JF - Endocrinology, Diabetes and Metabolism Case Reports
ER -