Study of the bioactive conformation of novel 5-HT<inf>4</inf> receptor ligands: Influence of an intramolecular hydrogen bond

María L. López-Rodríguez, Bellinda Benhamú, Alma Viso, Marta Murcia, Leonardo Pardo

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9 Citations (Scopus)

Abstract

By using NMR and IR techniques and theoretical methods, we have studied the prototropic equilibrium present in the benzimidazole ring of a series of derivatives acting at serotonin 5-HT4 receptors. The structural study has allowed us to get insight into the bioactive conformation of the novel 5-HT4 receptor ligands which has been supported by biological data. This will help the docking of the ligands into a 3-D model of the receptor binding site in order to guide the design and synthesis of new compounds with predetermined pharmacological activities. © 2001 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)6745-6749
JournalTetrahedron
Volume57
DOIs
Publication statusPublished - 30 Jul 2001

Keywords

  • 5-HT receptor 4
  • Benzimidazoles
  • Hydrogen bonding
  • Tautomerism

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