Study of haemostatic disorders in experimentally induced leishmaniasis in Beagle dogs

Josep Enric Valladares, Rafael Ruiz De Gopegui, Cristina Riera, Jordi Alberola, Montserrat Gállego, Yvonne Espada, Montserrat Portús, Margarita Arboix

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Haemostatic alterations in dogs experimentally infected with Leishmania infanTum were studied before and after therapy with meglumine antimonate. Haemostatic function tests including platelet count, collagen-induced platelet aggregation, prothrombin time, activated partial thromboplastin time, thrombin time, plasma fibrinogen determination, and serum fibrinogen/fibrin degradation products concentration were performed. In the course of infection and before treatment, moderate thrombocytopenia (P<0·00001), decreased collagen induced platelet aggregation (P=0.0003), prolonged thrombin time (P=0.0117) and increased fibrinogen/fibrin degradation products were observed. Statistically significant differences of plasma fibrinogen concentration, prothrombin time, and activated partial thromboplastin time were not encountered. Haemostatic parameters returned to normal values after therapy. The results indicate that Leishmania infection may impair haemostasis suggesting induction of disseminated intravascular coagulation (DIC), and that treating dogs in an early stage of infection may potentially avoid the possibility of developing an uncompensated DIC.
Original languageEnglish
Pages (from-to)195-198
JournalResearch in Veterinary Science
Volume64
DOIs
Publication statusPublished - 1 Jan 1998

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