Studies of the antiproliferative activity of ruthenium (II) Cyclopentadienyl-derived complexes with nitrogen coordinated ligands

Virtudes Moreno, Julia Lorenzo, Francesc X. Aviles, M. Helena Garcia, Joo P. Ribeiro, Tnia S. Morais, Pedro Florindo, M. Paula Robalo

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Abstract

Four cationic ruthenium(II) complexes with the formula [ Ru(n 5 -C 5 H 5 ) (PPh 3 ) 2 ] + , with L=5 -phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b;4,3- b ′ ] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR 322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs. Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells). Copyright © 2010 Virtudes Moreno et al.
Original languageEnglish
Article number936834
Pages (from-to)-
JournalBioinorganic Chemistry and Applications
Volume2010
DOIs
Publication statusPublished - 20 Jul 2010

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