Structure of three Ribonuclease-A covalent derivatives with pyridoxal 5′-phosphate

Lluís Boqué, Maria G. Coll, Marc Ribó, Claudi M. Cuchillo, Ignacio Fita, Maria Vilanova

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The crystal structure of three bovine pancreatic ribonuclease derivatives modified covalently with pyridoxal 5-phosphate at Lys-1 (derivative A), Lys-7 (derivative B) and Lys-41 (derivative C) has been determined. The structures found provide an explanation of the kinetic parameters obtained for derivatives A and B. In addition, these structures permit to postulate the contribution of Lys-7 and Lys-66 to the catalytic mechanism of ribonuclease A.
Original languageEnglish
Pages (from-to)101-108
JournalProtein and Peptide Letters
Volume5
Issue number2
Publication statusPublished - 1 Dec 1998

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