Structural plasticity in hippocampal cells related to the facilitative effect of intracranial self-stimulation on a spatial memory task

J Chamorro-López, M Miguéns, I Morgado-Bernal, Asta Kastanauskaite, Abraham Selvas, Alberto Cabané-Cucurella, Laura Aldavert-Vera, Javier DeFelipe, Pilar Segura-Torres

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

© 2015 American Psychological Association. Posttraining intracranial self-stimulation (SS) in the lateral hypothalamus facilitates the acquisition and retention of several implicit and explicit memory tasks. Here, intracellular injections of Lucifer yellow were used to assess morphological changes in hippocampal neurons that might be specifically related to the facilitative posttraining SS effect upon the acquisition and retention of a distributed spatial task in the Morris water maze. We examined the structure, size and branching complexity of cornus ammonis 1 (CA1) cells, and the spine density of CA1 pyramidal neurons and granular cells of the dentate gyrus (DG). Animals that received SS after each acquisition session performed faster and better than Sham ones-an improvement that was also evident in a probe trial 3 days after the last training session. The neuromorphological analysis revealed an increment in the size and branching complexity in apical CA1 dendritic arborization in SS-treated subjects as compared with Sham animals. Furthermore, increased spine density was observed in the CA1 field in SS animals, whereas no effects were observed in DG cells. Our results support the hypothesis that the facilitating effect of SS on the acquisition and retention of a spatial memory task could be related to structural plasticity in CA1 hippocampal cells.
Original languageEnglish
Pages (from-to)720-730
JournalBehavioral Neuroscience
Volume129
Issue number6
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • Apical and basal branching
  • CA1 pyramidal neurons
  • Deep brain stimulation
  • Dendritic spines
  • Intracellular injections

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