Background: Formyl peptide receptor 1 (FPR1) and FPR2 are highly homologous but bind fMet-Leu-Phe with very different affinities. Results: Asp-281 provides a negative charge that renders FPR2 more sensitive to the length and composition of formyl peptides than FPR1. Conclusion: Asp-281 is a major determinant for FPR2 binding. Significance: This work provides a structural basis for differential interaction between formyl peptides and their receptors. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 24 Jan 2014|