Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands

Hui Qiong He, Erica L. Troksa, Gianluigi Caltabiano, Leonardo Pardo, Richard D. Ye

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Abstract

Background: Formyl peptide receptor 1 (FPR1) and FPR2 are highly homologous but bind fMet-Leu-Phe with very different affinities. Results: Asp-281 provides a negative charge that renders FPR2 more sensitive to the length and composition of formyl peptides than FPR1. Conclusion: Asp-281 is a major determinant for FPR2 binding. Significance: This work provides a structural basis for differential interaction between formyl peptides and their receptors. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Original languageEnglish
Pages (from-to)2295-2306
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
Publication statusPublished - 24 Jan 2014

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