Stromal tumours of the gastrointestinal tract: a clinicopathological and ploidy analysis of 33 cases

E. Lerma; E. Oliva; D. Tugués; J. Prat

doi:https://doi.org/10.1007/BF00197388

Stromal tumours of the gastrointestinal tract: a clinicopathological and ploidy analysis of 33 cases

E. Lerma, E. Oliva, D. Tugués, J. Prat

Department of Morphological Sciences

Research output: Contribution to journal › Article › Research › peer-review

53 Citations (Scopus)

Abstract

The clinicopathological and DNA flow cytometric data of 33 patients with stromal tumours of the gastrointestinal tract (STGIT) were analysed to select pathological features of prognostic value. Tumours had been previously classified as benign (21 cases) or malignant (12 cases). Data relating to poor prognosis statistically were local invasion, pathological grade, size greater than 10 cm, mitotic index (MI) and necrosis. Pathological grade was related to local invasion. Aneuploidy did not correlate with poor survival although a common trend was detected between both. DNA content may help to predict prognosis of STGIT, but its real value has not yet been clearly established. Currently, stage (invasion), size, MI and pathological grade remain the most useful prognostic factors. © 1994 Springer-Verlag.

Original language	English
Pages (from-to)	19-24
Journal	Virchows Archiv
Volume	424
DOIs	https://doi.org/10.1007/BF00197388
Publication status	Published - 1 Jan 1994

Keywords

Flow cytometry
Gastrointestinal tract
Ploidy
Smooth muscle tumours
Stromal tumours

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title = "Stromal tumours of the gastrointestinal tract: a clinicopathological and ploidy analysis of 33 cases",

abstract = "The clinicopathological and DNA flow cytometric data of 33 patients with stromal tumours of the gastrointestinal tract (STGIT) were analysed to select pathological features of prognostic value. Tumours had been previously classified as benign (21 cases) or malignant (12 cases). Data relating to poor prognosis statistically were local invasion, pathological grade, size greater than 10 cm, mitotic index (MI) and necrosis. Pathological grade was related to local invasion. Aneuploidy did not correlate with poor survival although a common trend was detected between both. DNA content may help to predict prognosis of STGIT, but its real value has not yet been clearly established. Currently, stage (invasion), size, MI and pathological grade remain the most useful prognostic factors. {\textcopyright} 1994 Springer-Verlag.",

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author = "E. Lerma and E. Oliva and D. Tugu{\'e}s and J. Prat",

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T1 - Stromal tumours of the gastrointestinal tract: a clinicopathological and ploidy analysis of 33 cases

AU - Lerma, E.

AU - Oliva, E.

AU - Tugués, D.

AU - Prat, J.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The clinicopathological and DNA flow cytometric data of 33 patients with stromal tumours of the gastrointestinal tract (STGIT) were analysed to select pathological features of prognostic value. Tumours had been previously classified as benign (21 cases) or malignant (12 cases). Data relating to poor prognosis statistically were local invasion, pathological grade, size greater than 10 cm, mitotic index (MI) and necrosis. Pathological grade was related to local invasion. Aneuploidy did not correlate with poor survival although a common trend was detected between both. DNA content may help to predict prognosis of STGIT, but its real value has not yet been clearly established. Currently, stage (invasion), size, MI and pathological grade remain the most useful prognostic factors. © 1994 Springer-Verlag.

AB - The clinicopathological and DNA flow cytometric data of 33 patients with stromal tumours of the gastrointestinal tract (STGIT) were analysed to select pathological features of prognostic value. Tumours had been previously classified as benign (21 cases) or malignant (12 cases). Data relating to poor prognosis statistically were local invasion, pathological grade, size greater than 10 cm, mitotic index (MI) and necrosis. Pathological grade was related to local invasion. Aneuploidy did not correlate with poor survival although a common trend was detected between both. DNA content may help to predict prognosis of STGIT, but its real value has not yet been clearly established. Currently, stage (invasion), size, MI and pathological grade remain the most useful prognostic factors. © 1994 Springer-Verlag.

KW - Flow cytometry

KW - Gastrointestinal tract

KW - Ploidy

KW - Smooth muscle tumours

KW - Stromal tumours

U2 - https://doi.org/10.1007/BF00197388

DO - https://doi.org/10.1007/BF00197388

M3 - Article

VL - 424

SP - 19

EP - 24

JO - Virchows Archiv

JF - Virchows Archiv

SN - 0945-6317

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