Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome

Óscar M. Peiró, Nuria Farré, German Cediel, Gil Bonet, Sergio Rojas, Verónica Quintern, Alfredo Bardají

    Research output: Contribution to journalArticleResearch

    Abstract

    © 2019 Future Medicine Ltd. Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2-5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1-3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 95% CI: 0.423-0.681; p = 0.027). Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors.
    Original languageEnglish
    Pages (from-to)1187-1198
    JournalBiomarkers in Medicine
    Volume13
    DOIs
    Publication statusPublished - 1 Jan 2019

    Keywords

    • acute coronary syndrome
    • biomarker
    • heart failure
    • long-term
    • myocardial infarction
    • NSTEMI
    • prognosis
    • STEMI
    • stromal cell derived factor-1
    • unstable angina

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  • Cite this

    Peiró, Ó. M., Farré, N., Cediel, G., Bonet, G., Rojas, S., Quintern, V., & Bardají, A. (2019). Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome. Biomarkers in Medicine, 13, 1187-1198. https://doi.org/10.2217/bmm-2019-0133