Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome

Óscar M. Peiró; Nuria Farré; German Cediel; Gil Bonet; Sergio Rojas; Verónica Quintern; Alfredo Bardají

doi:10.2217/bmm-2019-0133

Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome

Óscar M. Peiró, Nuria Farré, German Cediel, Gil Bonet, Sergio Rojas, Verónica Quintern, Alfredo Bardají

Research output: Contribution to journal › Article › Research

Abstract

© 2019 Future Medicine Ltd. Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2-5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1-3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 95% CI: 0.423-0.681; p = 0.027). Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors.

Original language	English
Pages (from-to)	1187-1198
Journal	Biomarkers in Medicine
Volume	13
DOIs	https://doi.org/10.2217/bmm-2019-0133
Publication status	Published - 1 Jan 2019

Keywords

acute coronary syndrome
biomarker
heart failure
long-term
myocardial infarction
NSTEMI
prognosis
STEMI
stromal cell derived factor-1
unstable angina

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@article{f065907915e74fd7ad459311534cb503,

title = "Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome",

abstract = "{\textcopyright} 2019 Future Medicine Ltd. Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2-5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1-3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 95% CI: 0.423-0.681; p = 0.027). Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors.",

keywords = "acute coronary syndrome, biomarker, heart failure, long-term, myocardial infarction, NSTEMI, prognosis, STEMI, stromal cell derived factor-1, unstable angina",

author = "Peir{\'o}, {{\'O}scar M.} and Nuria Farr{\'e} and German Cediel and Gil Bonet and Sergio Rojas and Ver{\'o}nica Quintern and Alfredo Bardaj{\'i}",

year = "2019",

month = jan,

day = "1",

doi = "10.2217/bmm-2019-0133",

language = "English",

volume = "13",

pages = "1187--1198",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

}

TY - JOUR

T1 - Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome

AU - Peiró, Óscar M.

AU - Farré, Nuria

AU - Cediel, German

AU - Bonet, Gil

AU - Rojas, Sergio

AU - Quintern, Verónica

AU - Bardají, Alfredo

PY - 2019/1/1

Y1 - 2019/1/1

N2 - © 2019 Future Medicine Ltd. Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2-5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1-3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 95% CI: 0.423-0.681; p = 0.027). Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors.

AB - © 2019 Future Medicine Ltd. Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2-5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1-3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 95% CI: 0.423-0.681; p = 0.027). Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors.

KW - acute coronary syndrome

KW - biomarker

KW - heart failure

KW - long-term

KW - myocardial infarction

KW - NSTEMI

KW - prognosis

KW - STEMI

KW - stromal cell derived factor-1

KW - unstable angina

U2 - 10.2217/bmm-2019-0133

DO - 10.2217/bmm-2019-0133

M3 - Article

C2 - 31559838

VL - 13

SP - 1187

EP - 1198

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

SN - 1752-0363

ER -