Abstract
© 2019 Future Medicine Ltd. Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2-5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1-3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 95% CI: 0.423-0.681; p = 0.027). Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors.
| Original language | English |
|---|---|
| Pages (from-to) | 1187-1198 |
| Journal | Biomarkers in Medicine |
| Volume | 13 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
Keywords
- acute coronary syndrome
- biomarker
- heart failure
- long-term
- myocardial infarction
- NSTEMI
- prognosis
- STEMI
- stromal cell derived factor-1
- unstable angina
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Peiró, Ó. M., Farré, N., Cediel, G., Bonet, G., Rojas, S., Quintern, V., & Bardají, A. (2019). Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome. Biomarkers in Medicine, 13, 1187-1198. https://doi.org/10.2217/bmm-2019-0133