Stress response in the central nervous system of a transgenic mouse model of bovine spongiform encephalopathy

Raül Tortosa, Enric Vidal, Carme Costa, Elia Alamillo, Juan Maria Torres, Isidre Ferrer, Martí Pumarola*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

An immunohistochemical study was performed to evaluate the stress-related proteins heat shock protein 25 (HSP25) and metallothionein 1 + 2 (MT1 + 2) in the brains of a murine model of bovine spongiform encephalopathy (BSE). Transgenic mice (BoTg110) expressing the bovine cellular prion protein were intracerebrally inoculated with brainstem homogenate from BSE infected cattle. PrPBSE deposits were found in the brain as early as 150 days post-inoculation (dpi) and in mice sacrificed terminally at 290-320 dpi. Glial proliferation and spongiform change were associated with an increase in glial immunostaining of MT1 + 2 and HSP25, respectively. These proteins are associated with oxidative stress and heavy metal metabolism, which may have a role in the pathogenesis of BSE.

Original languageAmerican English
Pages (from-to)126-129
Number of pages4
JournalVeterinary Journal
Volume178
Issue number1
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Bovine spongiform encephalopathy
  • Glia
  • Mouse model
  • Pathogenesis
  • Prion
  • Stress

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