Abstract

Fear extinction alterations are a core symptom of post-traumatic stress disorder(PTSD). Traditionally, animal models of fear extinction mainly use male subjects. Recently, more studies on fear extinction are including sex as a biological variable and thus also test females. We describe here how to induce impairments in fear extinction in both male and female mice by previously exposing them to acute stress immobilization.

Original languageEnglish
Title of host publicationNeuromethods
Subtitle of host publicationTranslational Methods for PTSD Research
EditorsGraziano Pinna
Pages191-201
Number of pages11
Volume198
ISBN (Electronic)978-1-0716-3218-5
DOIs
Publication statusPublished - 2023

Publication series

NameNeuromethods
Volume198

Keywords

  • Acute stress
  • Animal model
  • Fear extinction
  • Immobilization
  • Sex as a biological variable

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