Estrategias para optimizar la adherencia al tratamiento antirretroviral. Intervenciones en la pauta terapéutica

Translated title of the contribution: Strategies to optimize adherence to antiretroviral treatment. Interventions in the therapeutic regimen

Hernando Knobel*, Ana Guelar

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

12 Citations (Scopus)

Abstract

Within the first few years after the introduction of highly active antiretroviral therapy two facts became evident: the treatment was highly effective and proper compliance was essential to achieve the therapeutic objectives. Recently, the regimens containing these drugs have changed. Complex dosing with a large number of tablets taken three times daily together with dietary restrictions has given way to simpler treatments. The main advances include new formulations and new drugs that allow once-daily dosing, the use of ritonavir to enhance the bioavailability of the protease inhibitors and the coformulation of active ingredients in a single capsule. This review analyzes the impact of these interventions on the therapeutic regimen and it discusses the factors that facilitate and those that hinder optimal adherence to highly active antiviral treatment. Adherence is a complex, multidimensional problem. Simplification of the treatment is an important aspect, but it should be accompanied by other strategies focussed on the patient and the medical team in order to achieve effective long-term antiretroviral therapy in all patients.

Translated title of the contributionStrategies to optimize adherence to antiretroviral treatment. Interventions in the therapeutic regimen
Original languageSpanish
Pages (from-to)106-112
Number of pages7
JournalEnfermedades Infecciosas y Microbiologia Clinica
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 2004

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