A sterile pustular skin eruption was observed in 17 of 3.541 newborn infants examined over a period of 30 months. The skin eruption was always present at birth and fulfilled the clinical criteria of transient neonatal pustular melanosis (TNPM). However, some days after birth, all of them but 1 developed skin lesions typical of erythema toxicum neonatorum (ETN). Histological examination of 11 biopsies obtained at the age of 1 day showed intracorncal neutrophilic pustules in 4 and subcorneal intracpidcrmic eosinophilic pustules in 7. On the basis of our findings and a literature review we consider that a clear-cut differentiation between TNPM and ETN is not always possible. We propose the name sterile transient neonatal pustulosis to unify these conditions. © 1992 S. Karger AG, Basel.
- Erythema toxicum neonatorum
- Neonatal rash
- Pustular disorders
- Sterile pustulosis
- Toxic erythema
- Transient neonatal pustular melanosis
Ferrándiz, C., Coroleu, W., Ribera, M., Lorenzo, J. C., & Natat, A. (1992). Sterile transient neonatal pustulosis is a precocious form of erythema toxicum neonatorum. Dermatology, 185(1), 18-22. https://doi.org/10.1159/000247396