Stereotaxic Injection of Tetanus Toxin in Rat Central Nervous System Causes Alteration in Normal Levels of Monoamines

José Aguilera, Lluis Arístides López, Francesc González‐Sastre

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11 Citations (Scopus)

Abstract

Abstract: A single intraventricular injection of tetanus toxin produced a time‐dependent elevation of serotonin levels in brain and spinal cord of adult rats. This tetanus toxin‐induced increase was produced in areas of high density of serotonergic innervation, such as the hypothalamus, hippocampus, and spinal cord. Little or no effect was found in the thalamus, cerebellum, and frontal cortex, areas that are poorly innervated by serotonergic terminals. The responses of catechol‐amines (no change in dopamine level and generalized decrease in norepinephrine) pointed to a specific action of tetanus toxin on the serotonergic system. Stereotaxic injections of tetanus toxin in dorsal or magnus raphe nuclei did not have an evident effect on biogenic amine levels in the brain and spinal cord, respectively. Because direct stereotaxic injections of the toxin in the hypothalamus or hippocampus produced significant serotonin increases in both areas, it is proposed that tetanus toxin interacts with presynaptic targets to produce serotonin accumulation; this is probably due in part to an activation of tryptophan 5‐hydroxylase. Copyright © 1991, Wiley Blackwell. All rights reserved
Original languageEnglish
Pages (from-to)733-738
JournalJournal of Neurochemistry
Volume56
Issue number3
DOIs
Publication statusPublished - 1 Jan 1991

Keywords

  • 5‐Hydroxytryptamine
  • Biogenic amines
  • Rat
  • Regional distribution
  • Serotonin
  • Stereotaxic injection
  • Tetanus toxin

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