Abstract
Ethyl cinnamate reacts with several para-substituted aryl iodides under Jeffery-Larock conditions (Pd(OAc)2, NaHCO3, n-Bu4NBr, DMF, Δ) to give ethyl (E)-3-aryl-3-phenylpropenoates as major compounds. The reaction of para-substituted ethyl cinnamates with iodobenzene under analogous conditions affords the corresponding Z isomers. The initially stereodefined alkene formed under Heck conditions undergoes a slow isomerization.
Original language | English |
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Pages (from-to) | 7449-7452 |
Journal | Tetrahedron Letters |
Volume | 37 |
Issue number | 41 |
DOIs | |
Publication status | Published - 7 Oct 1996 |