Stereoselective synthesis of cyclobutyl γ-amino acids leading to branched peptides with a cyclobutane core

Jordi Aguilera, Raquel Gutiérrez-Abad, Àlex Mor, Albertina G. Moglioni, Graciela Y. Moltrasio, Rosa M. Ortuño

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Alternative synthetic routes are provided to synthesize γ-amino acids in their free form or conveniently protected for their selective incorporation into ramified γ-peptides with a cyclobutane core. The key synthetic-step involves the stereoselective conjugate addition of nitromethane to chiral cyclobutyl alkenoates prepared from (-)-verbenone. © 2008.
Original languageEnglish
Pages (from-to)2864-2869
JournalTetrahedron Asymmetry
Volume19
Issue number24
DOIs
Publication statusPublished - 12 Dec 2008

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