Stereoselective synthesis of chiral precursors to cyclobutane carbocyclic nucleosides and oligopeptides

Pablo D. Rouge, Albertina G. Moglioni, Graciela Y. Moltrasio, Rosa M. Ortuño

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Versatile and highly efficient synthetic routes leading to optically active cyclobutanones, γ-amino acids and δ-amino alcohols are described. These compounds are relevant synthetic precursors to enantiopure cyclobutane carbocyclic nucleosides and oligopeptides. (-)-(S)-Verbenone is the chiral starting material used and the key synthetic steps involve concerted rearrangements in acidic medium. © 2003 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)193-195
JournalTetrahedron Asymmetry
Volume14
Issue number2
DOIs
Publication statusPublished - 17 Jan 2003

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