The four stereoisomers of protected cyclobutane-1,2-diamine have been prepared in an enantio- and diastereocontrolled manner through stereodivergent synthetic routes starting from a half-ester as a common chiral precursor. Orthogonal protection allows the chemoselective manipulation of both amino groups as shown in this work. © 2012 American Chemical Society.
|Publication status||Published - 18 May 2012|
Sans, M., Illa, O., & Ortuño, R. M. (2012). Stereoselective synthesis of all stereoisomers of orthogonally protected cyclobutane-1,2-diamine and some chemoselective transformations. Organic Letters, 14(10), 2431-2433. https://doi.org/10.1021/ol300689e